Cell-permeable, peptide aldehyde inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM). Also a potent inhibitor of cathepsin L (Ki = 0.6 nM), the strongest inhibitor of cathepsin B (Ki = 100 nM) and inhibits proteasome chymotrypsin-like activity at micromolar concentration. Inhibition of calpains can activate autophagy.
产品描述
Proteasome inhibitor, chymotrypsin-like (beta5) activity. Calpain inhibitor. Cathepsin B / L inhibitor
