Clathrin light chain B （CLTB） is a member of the clathrin light chain family. Clathrin is a protein that has a key role in the formation of coated vesicles. CLTB functions as the key structural component of the lattice-type cytoplasmic face of coated pits and vesicles which capture certain macromolecules during receptor-mediated endocytosis. CLTB forms a triskelion form comprised of 3 clathrin heavy chains and 3 light chains. When the triskelia interact they form a polyhedral pattern which encircles the vesicle. CME （Clathrin-mediated endocytosis） controls numerous cellular physiological processes such as the internalization of growth factors and receptors， entry of pathogens， and synaptic transmission.
