CHMP4A is a member of the SNF7 family and operates as chromatin-modifying protein. CHMP4A is a key component of the endosomal sorting vital for transport complex III （ESCRT-III） which takes part in multivesicular bodies （MVBs） formation and sorting of endosomal cargo proteins into MVBs. Additionally， during HIV-1 infection， the virus utilizes the ESCRT-III complex to facilitate budding and exocytosis of viral proteins through the connection of CHMP4 and a protein engaged by HIV-1 p6， which exists in viral Gag assembly and budding. CHMP4A is expressed in higher quantities in skeletal muscle， kidney， liver and heart.
