This intronless gene encodes a member of the SRY-relatednHMG-box (SOX) family of transcription factors involved in thenregulation of embryonic development and in the determination ofncell fate. The product of this gene is required for stem-cellnmaintenance in the central nervous system, and also regulates genenexpression in the stomach. Mutations in this gene have beennassociated with optic nerve hypoplasia and with syndromicnmicrophthalmia, a severe form of structural eye malformation. Thisngene lies within an intron of another gene called SOX2 overlappingntranscript (SOX2OT).
应用类型
WB
免疫原
This Sox2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S249 of human Sox2.
