GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins. ARHGAP20 (Rho GTPase activating protein 20), also known as KIAA1391, is a 1,191 amino acid protein that contains one PH domain, one Ras-associating domain and one Rho-GAP domain. Expressed primarily in brain, but also present in lymph nodes and fetal liver, ARHGAP20 functions as a GTPase-activating protein for Rho-type GTPases, effectively converting Rho-type GTPases to an inactive, GDP-bound state. ARHGAP20 exists as multiple isoforms that are produced via alternative splicing. Chromosomal aberrations involving the ARHGAP20 gene are thought to be a cause of B-cell chronic lymphocytic leukemia (B-CLL).
应用类型
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免疫原
A synthetic peptide corresponding to residues in Human ARHGAP20
