CLC-KA is a kidney-specific chloride channel that mediates transepithelial chloride transport in the thin ascending limb of the Henle loop in the inner medulla. CLC-KA plays a crucial role in urine concentration. The gene encoding human CLC-KA maps to chromosome 1p36. Mutations in this gene may be associated with nephrogenic diabetes insipidus in those cases where mutations in the vasopressin V2 receptor and the AQP2 water channel are lacking. CLC-KB mediates basolateral chloride ion efflux in the thick ascending limb and in more distal nephron segments. The gene encoding human CLC-KB maps to chromosome 1p36. Mutations in this gene cause type III Barter’s syndrome which is characterized by renal salt-wasting and low blood pressure.
应用类型
该CLCNKA产品的应用类型详情查看产品说明书。
免疫原
Synthetic peptide, corresponding to amino acids 626-671 of Human CLCNKA.
来源宿主
rabbit
反应性
该Rabbit IgG polyclonal antibody for Claudin 2/CLDN2 detection. Tested with WB, ICC/IF, FCM, Direct ELISA in Human.产品的反应性详情查看产品说明书。
