FYCO1 encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in FYCO1 are a cause of autosomal recessive congenital cataract-2 (CATC2). FYCO1 (FYVE And Coiled-Coil Domain Containing 1) is a Protein Coding gene. Diseases associated with FYCO1 include Cataract 18, Autosomal Recessive and Early-Onset Nuclear Cataract.
