The protein encoded by CUL7 (Cullin 7) is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in CUL7 are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for CUL7. CUL7 is a Protein Coding gene. Diseases associated with CUL7 include 3-M Syndrome 1 and 3-M Syndrome, Cul7-Related. Among its related pathways are Class I MHC mediated antigen processing and presentation and Unfolded Protein Response (UPR).
