The β3 protein is an auxiliary subunit of the CaV (voltage dependent calcium) channel multimer complex. Four β isoforms were identified in mammalian genoms and they share some sequence as well as structure homology.1-3 The structure of CaVβ3 was recentely determined (as well as other CaVβ subunits; for review see reference 3). CaVβ subunits are cytoplasmic proteins, that bind the cytoplasmic face of the pore forming CaV α1 subunits. These interactions have profound effects on channel trafficing to the plasma membrane as well as on current parameters such as voltage dependent kinetics and interactions with modulatory proteins.1,2 CaVβ3 might interact with all the poreforming subunits that have been tested and in vivo is expressed in smooth muscle, trachea, aorta, lung and brain.1
Alomone Labs offers a polyclonal antibody directed against an epitope at the C-terminus of the auxiliary subunit CaVβ3.
