The mammalian Runt-related transcription factor （RUNX） family comprises three members，RUNX1 （also designated AML-1，PEBP2åB，CBFA2），RUNX2 （also designated AML-3，PEBP2åA，CBFA1，Osf2） and RUNX3 （also designated AML-2，PEBPåC，CBFA3）. RUNX family members are DNA-binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX2 is essential for skeletal mineralization in that it stimulates osteoblast differentiation of mesenchymal stem cells，promotes chondrocyte hypertrophy and contributes to endothelial cell migration and vascular invasion of developing bones. Regulating RUNX2 expression may be a useful therapeutic tool for promoting bone formation. Mutations in the C-terminus of RUNX2 are associated with cleidocranial dysplasia syndrome，an autosomal-dominant skeletal dysplasia syndrome that is characterized by widely patent calvarial sutures，clavicular hypoplasia，supernumerary teeth，and short stature.
This RUNX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 445-474 amino acids surrounding S533 of human RUNX2.
