TRAFs (TNF receptor associated proteins) form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6). TRAF3，originally named CRAF1，interacts directly with the CD40 cytoplasmic tail throμgh a region of similarity to the tumor necrosis factor-alpha (TNF-alpha) receptor-associated factors. TRAF3 binds only a single site，which contains the sequence PEQET，whereas TRAF1 and TRAF2 are capable of binding to either the PEQET site or an additional downstream domain.
应用类型
Western blot,
免疫原
Synthetic peptide corresponding to residues around amino acid 107 of human TWEAK Receptor
