Calmodulin-2 acts as an intracellular calcium sensor protein. When the intracellular Ca2+ concentration increases， calmodulin can bind up to four Ca2+， changing its conformation and regulating cellular functions such as activation or inhibition of a large number of enzymes， ion channels， and receptors. P53 protein stimulates CALM2 gene expression in 041 cells. CALM-2 is involved in the processes of Ca（2+）-induced neuronal cell death and the blockage of calmodulin attenuates brain injury after cerebral ischemia. Calmodulin-2 mediates the control of a large number of enzymes and other proteins by ca（2+）. among the enzymes to be stimulated by the calmodulin-ca（2+） complex are a number of protein kinases and phosphatases.
Store at 4℃ if entire vial will be used within 2-4 weeks.
Store， frozen at -20℃ for longer periods of time.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Avoid multiple freeze-thaw cycles.
