NAT1 is a member of the arylamine N-acetyltransferase family. NAT1 catalyzes N- or O-acetylation of heterocyclic and arylamine substrates in the detoxification of a large number of drugs. Several alleles triggering high levels of N-acetyltransferase activity were linked to colon and urinary bladder cancers， since NAT1 also bioactivate numerous known carcinogens. NAT1 aids metabolize drugs and other xenobiotics， and takes part in the detoxification of a plethora of hydrazine and arylamine drugs.
