A large protein complex, termed the anaphase-promoting
complex (APC), or the cyclosome, promotes metaphase-anaphase
transition by ubiquitinating its specific substrates such as
mitotic cyclins and anaphase inhibitor, which are subsequently
degraded by the 26S proteasome. Biochemical studies have shown that
the vertebrate APC contains eight subunits. The composition of the
APC is highly conserved in organisms from yeast to humans. The
exact function of this gene product is not known. [provided by
RefSeq].
