Synapsin I plays a key role in synaptic plasticity in brain (Feng et al.,
2002; Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate
the availability of synaptic vesicles for release. The role of synapsin in synaptic plasticity and in
synaptogensis is regulated by phosphorylation (Jovanovic et al., 2001; Kao et al., 2002). Ser 549
along with Ser 62 and Ser 67 are the sites of Synapsin I that are phosphorylated by MAP kinase
(Czernik et al., 1987; Jovanovic et al., 1996).
