Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002; Nayak
et al., 1996). This effect is due in large part to the ab
ility of the synapsins to regulate the availability of
synaptic vesicles for release. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by
phosphorylation (Jovanovic et al.,
2001; Kao et al., 2002). Ser
549
along with Ser
62
and Ser
67
are the sites of
synapsin I that are phosphorylated by MAP kinase (Jov
anovic et al., 1996). Phosphorylation and subsequent
dephosphorylation of this site is thought to play a key role in synaptic vesicle trafficking.
