This gene encodes a member of the cytochrome P450
superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug
metabolism and synthesis of cholesterol, steroids and other lipids.
This protein localizes to the endoplasmic reticulum and its
expression is induced by rifampin. The enzyme is known to
metabolize many xenobiotics, including phenytoin, tolbutamide,
ibuprofen and S-warfarin. Studies identifying individuals who are
poor metabolizers of phenytoin and tolbutamide suggest that this
gene is polymorphic. The gene is located within a cluster of
cytochrome P450 genes on chromosome 10q24.
