PSMB10 is a member of the proteasome B-type family （T1B family） which is a 20S core beta subunit. The proteasome is a multicatalytic proteinase complex with an extremely ordered ring-shaped 20S core structure. This core structure is comprised of four rings of 28 non-identical subunits； two rings are composed of seven alpha subunits and two rings are composed of seven beta subunits. Proteasomes are circulated in eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. A crucial function of a modified proteasome， the immunoproteasome， is the processing of class I MHC peptides. PSMB10 gene expression is induced by interferon-gamma， and it replaces catalytic subunit 2 （proteasome beta 7 subunit） in the immunoproteasome.
