RGS10 is a member of the RGS family that regulate molecules which perform as GTPase activating proteins （GAPs） for G alpha subunits of heterotrimeric G proteins. RGS proteins can disengage G protein subunits of the Gi alpha， Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. The nucleus localized RGS10 is associates specifically with the activated forms of the two related G-protein subunits， G-alphai3 and G-alphaz but is unable to cooperate with the structurally and functionally distinct G-alpha subunits.
