Tumor necrosis factor receptor superfamily member 8 （CD30） is a member of the TNF-receptor superfamily. CD30 is expressed by activated （not by resting） T and B cells. CD30 interacts with TRAF2 and TRAF5 which mediate the signal transduction that leads to the activation of NF-kappaB. CD30 is a positive regulator of apoptosis， and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.
