Death effector domain-containing protein （DEDD） is a cytoplasmic protein. The cell death activity of DEDD relates to its nuclear localization. DEDD translocates to the nucleus during CD95-mediated apoptosis， there it localizes to nucleoli-like structures， activates caspase-6 and particularly inhibits RNA polymerase I-dependent transcription. DEDD is usually expressed in a variety of tissues， and found in the highest levels in the testis. Overexpression of DEDD was shown to induce weak apoptosis.
