B-cell CLL/lymphoma 7A （BCL7A） is a member of the BCL7 family. BCL7A is directly involved， with Myc and IgH， in a three-way gene translocation in a Burkitt lymphoma cell line. Thru gene translocation， the N-terminal region of the BCL7A gene is disrupted， which is assumed to be connected to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal portion involved in the translocation includes the region which shares a compelling sequence similarity with those of BCL7B and BCL7C. Chromosomal anomalies involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma.
