Ubiquitin-like-conjugating enzyme ATG10 （ATG10） is a 220 amino acid protein which localizes to the cytoplasm and has a role in autophagy， specifically acting as an E2-like enzyme providing Atg recognition sites during autophagosome synthesis. ATG10 functions as an E2-like enzyme which catalyzes the conjugation of ATG12 to ATG5， which is required for autophagy. In addition， ATG10 interacts with ATG12 in human embryonic kidney cells in the presence of ATG7. ATG10 probably serves as an ATG5-recognition molecule. Furthermore， ATG10 has a role in adenovirus-mediated cell lysis.
