KLRC2 has a part as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. The group， designated KLRC （NKG2） are expressed mainly in natural killer （NK） cells and encodes a family of transmembrane proteins categorized by a type II membrane orientation （extracellular C terminus） and the presence of a C-type lectin domain. The KLRC （NKG2） gene family is situated inside the NK complex， a region which holds a few C-type lectin genes specially expressed on NK cells. KLRC2 alternative splice variants are known but their full-length nature is yet to be determined.
