Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid tryptophan by the enzyme tryptophan-decarboxylase. This conversion occurs in chromaffin and enteric cells whereas Serotonin reaches the central nervous system via blood circulation. In addition to its function as a neurotransmitter in the CNS it serves as a precursor for melatonin in the pineal gland. It can also be found in non-neuronal tissues such as the mucosa of gut and blood platelets. Serotonin is known to affect numerous behavioral and physiological functions.nThe 5-HT5B receptor is part of family of 13 known G-protein coupled receptors (GPCRs) divided into seven classes based on structural and operational features. Like other GPCRs, 5-HT5B receptor has an extracellular N-terminus, transmembrane domains and an intracellular C-terminal tail.
