MADCAM1 (Mucosal Vascular Addressin Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with MADCAM1 include Colitis and Inflammatory Bowel Disease. Among its related pathways are Paxillin-dependent events mediated by a4b1 and Cell adhesion molecules (CAMs). The protein encoded by MADCAM1 is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for MADCAM1, but the full-length nature of some variants has not been determined.
