HSP90 proteins are highly conserved molecular chaperones
that have key roles in signal transduction, protein folding,
protein degradation, and morphologic evolution. HSP90 proteins
normally associate with other cochaperones and play important roles
in folding newly synthesized proteins or stabilizing and refolding
denatured proteins after stress. HSP90B1 is an endoplasmic
reticulum HSP90 protein. Other HSP90 proteins are found in cytosol
(see HSP90AA1; MIM 140571) and mitochondria (TRAP1; MIM 606219)
(Chen et al., 2005 [PubMed 16269234]).
