Regulator of G protein signaling (RGS) family members are
regulatory molecules that act as GTPase activating proteins (GAPs)
for G alpha subunits of heterotrimeric G proteins. RGS proteins are
able to deactivate G protein subunits of the Gi alpha, Go alpha and
Gq alpha subtypes. They drive G proteins into their inactive
GDP-bound forms. Regulator of G protein signaling 2 belongs to this
family. The protein acts as a mediator of myeloid differentiation
and may play a role in leukemogenesis.
