The modification of proteins with ubiquitin is an
important cellular mechanism for targeting abnormal or short-lived
proteins for degradation. Ubiquitination involves at least three
classes of enzymes: ubiquitin-activating enzymes (E1s),
ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases
(E3s). This gene encodes a member of the E2 ubiquitin-conjugating
enzyme family. This enzyme is demonstrated to participate in the
ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in
vitro. Several alternatively spliced transcript variants have been
found for this gene.
