This gene was identified by the interaction of its gene
product with Grap2, a leukocyte-specific adaptor protein important
for immune cell signaling. The protein encoded by this gene was
shown to interact with cyclin D. Transfection of this gene in cells
was reported to reduce the phosphorylation of Rb gene product by
cyclin D-dependent protein kinase, and inhibit E2F1-mediated
transcription activity. This protein was also found to interact
with helix-loop-helix protein E12 and is thought to be a negative
regulator of liver-specific gene expression. Several alternatively
spliced variants have been found for this gene. [provided by
RefSeq].
