The A-kinase anchor proteins (AKAPs) are a group of
structurally diverse proteins, which have the common function of
binding to the regulatory subunit of protein kinase A (PKA) and
confining the holoenzyme to discrete locations within the cell.
This gene encodes a member of the AKAP family. The encoded protein
binds to the RII-beta regulatory subunit of PKA, and also to
protein kinase C and the phosphatase calcineurin. It is
predominantly expressed in cerebral cortex and may anchor the PKA
protein at postsynaptic densities (PSD) and be involved in the
regulation of postsynaptic events. It is also expressed in T
lymphocytes and may function to inhibit interleukin-2 transcription
by disrupting calcineurin-dependent dephosphorylation of NFAT.
