Synaptobrevin (aka VAMP) is an integral membrane protein of
synaptic vesicles that plays a major role in the formation of larger SNARE complexes, along
with SNAP-25 and syntaxin. Synaptobrevin has
been shown to be essential for two fast
synapse-specific membrane trafficking processes: fast exocytosis for neurotransmitter release
and fast endocytosis that mediates rapid recycling of synaptic vesicles (Deak et al., 2004).
Decreased levels of synaptobrevin in hum
an hippocampus and cortex have been correlated
with cognitive defects in Alzheimer
