The protein encoded by this gene is a member of the
TNF-receptor superfamily. This receptor is expressed by activated,
but not by resting, T and B cells. TRAF2 and TRAF5 can interact
with this receptor, and mediate the signal transduction that leads
to the activation of NF-kappaB. This receptor is a positive
regulator of apoptosis, and also has been shown to limit the
proliferative potential of autoreactive CD8 effector T cells and
protect the body against autoimmunity. Two alternatively spliced
transcript variants of this gene encoding distinct isoforms have
been reported.
