Phosphoinositide-dependent protein kinase-1 (PDK1) is a master kinase upstream of the AGC kinases (Akt, S6K, RSK, SGK, and PKC) that phosphorylates and activates these kinases in response to increases in the second messenger PtdIns-(3,4,5)-P3.{25772} PS-48 is a phosphopeptide mimetic that triggers PDK1 phosphorylation by binding exclusively to the PIF-binding pocket of PDK1 (Kd = 10.3 µM).{25773,25774} At 5 µM, it has been reported to enhance reprogramming efficiency of human primary somatic cells by 15-fold presumably by facilitating the metabolic conversion from mitochondrial oxidation to glycolysis.{25775}
产品描述
A phosphopeptide mimetic that activates PDK1 phosphorylation (Kd = 10.3 µM); 5 µM enhances reprogramming efficiency of human primary somatic cells
