DNA repair protein complementing XP-A cells， （XPA）， is a member of the XPA family. XPA protein takes a part in DNA excision repair. It Inductees repair by binding to damaged sites with different affinities depending on the photoproduct and the transcriptional state of the region. Defects in XPA is the reason of xeroderma pigmentosum complementation group A （XP-A）， which is infrequent human autosomal recessive disease which characterized by solar sensitivity， high predisposition for developing cancers on areas exposed to sunlight， also may cause to neurological abnormalities.
