Ang K1-3 is a single, non-glycosylated polypeptide chain containing 259 amino acids. It represents a proteolytic fragment of plasminogen containing the first three kringle structures. Ang K1-3 reduces endothelial cell proliferation and acts as a potent inhibitor of angiogenesis and tumor growth. It displays increased inhibitory activity(ED =70 nM) relative to kringles 1-4(ED = 135 nM).
产品描述
Ang K1-3是含有259个氨基酸的单一非糖基化多肽链。代表一种含有前三个三环结构的纤溶酶原蛋白水解片段。血管紧张素K1-3减少内皮细胞增殖，并作为血管生成和肿瘤生长的有效抑制剂。相对于三环域1-4（ED = 135 nM），它显示出增加的抑制活性（ED =70 nM）。
