Bcl10, also designated CIPER, c-CARMEN and mE10, was first identified as a gene truncated or mutated in MALT B cell lymphomas and other tumor types. Bcl10 is homologous to the equine herpesvirus-2 E10 gene and, like E10, it contains an N-terminal caspase recruitment domain (CARD). Expression of Bcl10 has been shown to induce NFKB activation in a NIK-dependent pathway, and research indicates that the CARD domain is essential for this activation; although in a separate study, Bcl10 by itself did not induce JNK or NFkB activation.
应用类型
WB
免疫原
Recombinant full length Human Bcl-10.
来源宿主
该B16-F10 Lysate产品的来源宿主详情查看产品说明书。
反应性
rabbit
保存建议
该Rabbit IgG polyclonal antibody for Ctip2/BCL11B detection. Tested with WB, Direct ELISA in Human;Mouse;Rat.产品的保存建议详情查看产品说明书。
