CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
应用类型
FC
免疫原
Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA.
来源宿主
该Rabbit IgG polyclonal antibody for Caveolin-1(CAV1) detection. Tested with WB, IHC, IHC-F, ICC in Human;Mouse;Rat.产品的来源宿主详情查看产品说明书。
