CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet; there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.
应用类型
FC
免疫原
Extracellular domain of human CD80 fused to human IgG1(Fc)
来源宿主
该Rabbit IgG polyclonal antibody for P-selectin(SELP) detection. Tested with WB, IHC, IHC-F, ICC, FCM, ELISA in Human.产品的来源宿主详情查看产品说明书。
