BAG family molecular chaperone regulator 3(BAG3) is a member of a conserved family of cyto-protective proteins that bind to and regulate Hsp70 family molecular chaperones. BAG3 mutations are responsible for familial dilated cardiomyopathy. BAG3 polymorphisms are also associated with sporadic forms of the disease together with HSPB7 locus. In muscle cells, BAG3 cooperates with the molecular chaperones Hsc70 and HspB8 to induce the degradation of mechanically damaged cytoskeleton components in lysosomes. This process is called chaperone-assisted selective autophagy(CASA) and is essential for maintaining muscle activity in flies, mice and men.
应用类型
IHC,WB
免疫原
A synthetic peptide corresponding to a sequence at the C-terminus of human Bag3(491-506aa LEKLEQKAIDVPGQVQ), identical to the related mouse and rat sequences.
