1-Pyrenebutyric acid N-hydroxysuccinimide ester is a chemical reagent featuring a polycyclic benzene framework known as pyrene ligated to an NHS ester. The NHS ester is a highly activated carboxylic acid which readily reacts with amines under mild conditions to form amides. Pyrene is a versatile material which may be derivatized to form fluorescent dyes or used in the surface functionalization of carbon nanotubes or graphene-derivatives to provide stability through pi-pi stacking between the pyrene and the aromatic rings of these compounds.