Contactin-associated protein 2 (Caspr2) is a member of the neurexin superfamily, a group of transmembrane proteins that mediate cell–cell interactions in the nervous system.nNeurexins are adhesion molecules expressed mainly at presynaptic locations that form trans-synaptic cell – cell adhesion complexes via binding to their postsynaptic partners the neuroligins.nCaspr2, like other neurexin proteins, is a type I membrane protein that contains epidermal growth factor repeats, laminin G domains, an F5/8 type C domain, and fibrinogen-like domains in its extracellular domain
