CD4 (MIM 186940)-positive T helper lymphocytes can be
divided into types 1 (Th1) and 2 (Th2) on the basis of their
cytokine secretion patterns. Th1 cells and their associated
cytokines are involved in cell-mediated immunity to intracellular
pathogens and delayed-type hypersensitivity reactions, whereas Th2
cells are involved in the control of extracellular helminthic
infections and the promotion of atopic and allergic diseases. The 2
types of cells also cross-regulate the functions of the other. TIM3
is a Th1-specific cell surface protein that regulates macrophage
activation and enhances the severity of experimental autoimmune
encephalomyelitis in mice.
