EpiQuik? 总组蛋白提取试剂盒是一整套优化的缓冲液和试剂，用于在简单的 60 分钟程序中从哺乳动物细胞或组织中提取总核心组蛋白（H2A、H2B、H3 和 H4）。组蛋白提取物中的翻译后修饰 （PTM） 保持完整，因此可与 Epigentek 的组蛋白修饰检测试剂盒一起使用，或用于组蛋白甲基化、乙酰化、磷酸化、苏木化、泛素化、瓜氨酸化和 ADP 核糖基化研究的各种下游应用。
预先优化且简单的 1 小时方案。
方便地包括进行组蛋白提取所需的所有必需试剂。
标准化程序，结果可重复。
从低至 1 mg 的组织中提取高产量的总核心组蛋白。
翻译后修饰保持完整。
不影响组蛋白修饰状态或水平。
| 产品名称 | 货号 | 规格 |
EpiQuik Total Histone Extraction Kit | OP-0006-100 | 100 extractions |
近400+文献鉴赏：
| 标题 | 作者 | 杂志名称 |
| Human histone acetyltransferase 1 (Hat1) acetylates lysine 5 of histone H2A in vivo. | Tafrova JI, Tafrov ST | Mol Cell Biochem |
| All-trans retinoic acid and sodium butyrate enhance natriuretic peptide receptor a gene transcription: role of histone modification. | Kumar P, Periyasamy R, Das S, Neerukonda S, Mani I, Pandey KN | Mol Pharmacol |
| Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. | Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB | Nature |
| A High-Throughput Fluorimetric Assay for 2-Hydroxyglutarate Identifies Zaprinast as a Glutaminase Inhibitor. | Elhammali A, Ippolito JE, Collins L, Crowley J, Marasa J, Piwnica-Worms D | Cancer Discov |
| Cardiac deletion of Smyd2 is dispensable for mouse heart development. | Diehl F, Brown MA, van Amerongen MJ, Novoyatleva T, Wietelmann A, Harriss J, Ferrazzi F, Böttger T, Harvey RP, Tucker PW, Engel FB | PLoS One |
| Development of a drug screening platform based on engineered heart tissue. | Hansen A, Eder A, Bönstrup M, Flato M, Mewe M, Schaaf S, Aksehirlioglu B, Schwoerer AP, Uebeler J, Eschenhagen T | Circ Res |
| Long interspersed nuclear element-1 hypomethylation is a potential biomarker for the prediction of response to oral fluoropyrimidines in microsatellite stable and CpG island methylator phenotype-negative colorectal cancer. | Kawakami K, Matsunoki A, Kaneko M, Saito K, Watanabe G, Minamoto T | Cancer Sci |
| Effect of the histone deacetylase inhibitors on behavioural sensitization to a single morphine exposure in mice. | Jing L, Luo J, Zhang M, Qin WJ, Li YL, Liu Q, Wang YT, Lawrence AJ, Liang JH | Neurosci Lett |
| TNF-a inhibits aquaporin 5 expression in human salivary gland acinar cells via suppression of histone H4 acetylation. | Yamamura Y, Motegi K, Kani K, Takano H, Momota Y, Aota K, Yamanoi T, Azuma M | J Cell Mol Med |
| Abnormal epigenetic modifications in peripheral blood mononuclear cells from patients with alopecia areata. | Zhao M, Liang G, Wu X, Wang S, Zhang P, Su Y, Yin H, Tan Y, Zhang J, Lu Q | Br J Dermatol |
| A molecular mechanism underlying ovarian dysfunction of polycystic ovary syndrome: hyperandrogenism induces epigenetic alterations in the granulosa cells. | Qu F, Wang FF, Yin R, Ding GL, El-Prince M, Gao Q, Shi BW, Pan HH, Huang YT, Jin M, Leung PC, Sheng JZ, Huang HF | J Mol Med (Berl) |
| Gene coexpression networks in human brain identify epigenetic modifications in alcohol dependence. | Ponomarev I, Wang S, Zhang L, Harris RA, Mayfield RD | J Neurosci |
| Myc regulates the transcription of the PRC2 gene to control the expression of developmental genes in embryonic stem cells. | Neri F, Zippo A, Krepelova A, Cherubini A, Rocchigiani M, Oliviero S | Mol Cell Biol |
| The HTLV-1-encoded protein HBZ directly inhibits the acetyl transferase activity of p300/CBP. | Wurm T, Wright DG, Polakowski N, Mesnard JM, Lemasson I | Nucleic Acids Res |
| Histone acetylation rescues contextual fear conditioning in nNOS KO mice and accelerates extinction of cued fear conditioning in wild type mice. | Itzhak Y, Anderson KL, Kelley JB, Petkov M | Neurobiol Learn Mem |
| Neonatal isolation decreases cued fear conditioning and frontal cortical histone 3 lysine 9 methylation in adult female rats. | Kao GS, Cheng LY, Chen LH, Tzeng WY, Cherng CG, Su CC, Wang CY, Yu L | Eur J Pharmacol |
| Sulforaphane causes a major epigenetic repression of myostatin in porcine satellite cells. | Fan H, Zhang R, Tesfaye D, Tholen E, Looft C, Hölker M, Schellander K, Cinar MU | Epigenetics |
| Perinatal nicotine exposure induces asthma in second generation offspring. | Rehan VK, Liu J, Naeem E, Tian J, Sakurai R, Kwong K, Akbari O, Torday JS | BMC Med |
| STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain. | Timofeeva OA, Tarasova NI, Zhang X, Chasovskikh S, Cheema AK, Wang H, Brown ML, Dritschilo A | Proc Natl Acad Sci U S A |
| EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. | McCabe MT, Ott HM, Ganji G, Korenchuk S, Thompson C, Van Aller GS, Liu Y, Graves AP, Della Pietra A 3rd, Diaz E, LaFrance LV, Mellinger M, Duquenne C, Tian X, Kruger RG, McHugh CF, Brandt M, Miller WH, Dhanak D, Verma SK, Tummino PJ, Creasy CL | Nature |
| Aberrant histone modifications in peripheral blood mononuclear cells from patients with Henoch-Schönlein purpura. | Luo S, Liang G, Zhang P, Zhao M, Lu Q | Clin Immunol |
| Anticancer efficacy of cisplatin and trichostatin A or 5-aza-2'-deoxycytidine on ovarian cancer. | Meng F, Sun G, Zhong M, Yu Y, Brewer MA | Br J Cancer |
| Croton lechleri Müll. Arg. (Euphorbiaceae) stem bark essential oil as possible mutagen-protective food ingredient against heterocyclic amines from cooked food. | Rossi D, Guerrini A, Paganetto G, Bernacchia G, Conforti F, Statti G, Maietti S, Poppi I, Tacchini M, Sacchetti G | Food Chem |
| Sodium butyrate-induced histone acetylation strengthens the expression of cocaine-associated contextual memory. | Itzhak Y, Liddie S, Anderson KL | Neurobiol Learn Mem |
| Synthesis, Activity and Metabolic Stability of Non-Ribose Containing Inhibitors of Histone Methyltransferase DOT1L. | Deng L, Zhang L, Yao Y, Wang C, Redell MS, Dong S, Song Y | Medchemcomm |
| Analysis of epigenetic factors in mouse embryonic neural stem cells exposed to hyperglycemia. | Shyamasundar S, Jadhav SP, Bay BH, Tay SS, Kumar SD, Rangasamy D, Dheen ST | PLoS One |
| The p53 pathway induction is not primarily dependent on Ataxia Telangiectasia Mutated (ATM) gene activity after fludarabine treatment in chronic lymphocytic leukemia cells. | Navrkalova V, Sebejova L, Zemanova J, Jaskova Z, Trbusek M | Leuk Lymphoma |
| Methamphetamine-Associated Memory Is Regulated by a Writer and an Eraser of Permissive Histone Methylation. | Aguilar-Valles A, Vaissière T, Griggs EM, Mikaelsson MA, Takács IF, Young EJ, Rumbaugh G, Miller CA | Biol Psychiatry |
| Triazole-dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration. | Zheng YC, Duan YC, Ma JL, Xu RM, Zi X, Lv WL, Wang MM, Ye XW, Zhu S, Mobley D, Zhu YY, Wang JW, Li JF, Wang ZR, Zhao W, Liu HM | J Med Chem |
| Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailability. | Jochems J, Boulden J, Lee BG, Blendy JA, Jarpe M, Mazitschek R, Van Duzer JH, Jones S, Berton O | Neuropsychopharmacology |
| Histone deacetylase inhibitors modulate the transcriptional regulation of guanylyl cyclase/natriuretic peptide receptor-a gene: interactive roles of modified histones, histone acetyltransferase, p300, AND Sp1. | Kumar P, Tripathi S, Pandey KN | J Biol Chem |
| Histone acetylation and expression of mono-aminergic transmitters synthetases involved in CUS-induced depressive rats. | Liu D, Qiu HM, Fei HZ, Hu XY, Xia HJ, Wang LJ, Qin LJ, Jiang XH, Zhou QX | Exp Biol Med (Maywood) |
| H2AX phosphorylation regulated by p38 is involved in Bim expression and apoptosis in chronic myelogenous leukemia cells induced by imatinib. | Dong Y, Xiong M, Duan L, Liu Z, Niu T, Luo Y, Wu X, Xu C, Lu C | Apoptosis |
| Social isolation-induced epigenetic changes in midbrain of adult mice. | Siuda D, Wu Z, Chen Y, Guo L, Linke M, Zechner U, Xia N, Reifenberg G, Kleinert H, Forstermann U, Li H | J Physiol Pharmacol |
| Feeding a high-concentrate corn straw diet induced epigenetic alterations in the mammary tissue of dairy cows. | Dong G, Qiu M, Ao C, Zhou J, Khas-Erdene, Wang X, Zhang Z, Yang Y | PLoS One |
| High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity. | Schulz MD, Atay C, Heringer J, Romrig FK, Schwitalla S, Aydin B, Ziegler PK, Varga J, Reindl W, Pommerenke C, Salinas-Riester G, B??ck A, Alpert C, Blaut M, Polson SC, Brandl L, Kirchner T, Greten FR, Polson SW, Arkan MC | Nature |
| Maternal high-zinc diet attenuates intestinal inflammation by reducing DNA methylation and elevating H3K9 acetylation in the A20 promoter of offspring chicks. | Li C, Guo S, Gao J, Guo Y, Du E, Lv Z, Zhang B | J Nutr Biochem |
| Histone H3 Phosphorylation in GBM: a New Rational to Guide the Use of Kinase Inhibitors in anti-GBM Therapy. | Pacaud R, Cheray M, Nadaradjane A, Vallette FM, Cartron PF | Theranostics |
| Ubiquitinated proteins in exosomes secreted by myeloid-derived suppressor cells. | Burke MC, Oei MS, Edwards NJ, Ostrand-Rosenberg S, Fenselau C | J Proteome Res |
| Top??“down analysis of low mass proteins in exosomes shed by murine myeloid-derived suppressor cells | Geis-Asteggiante L, | International Journal of Mass Spectrometry |
| DNA methylation and histone modification patterns during the late embryonic and early postnatal development of chickens. | Li C, Guo S, Zhang M, Gao J, Guo Y | Poult Sci |
| Liver histone H3 methylation and acetylation may associate with type 2 diabetes development. | Tu P, Li X, Ma B, Duan H, Zhang Y, Wu R, Ni Z, Jiang P, Wang H, Li M, Zhu J, Li M | J Physiol Biochem |
| Small antisense oligonucleotides against G-quadruplexes: specific mRNA translational switches. | Rouleau SG, Beaudoin JD, Bisaillon M, Perreault JP | Nucleic Acids Res |
| Design, Synthesis, and Structure-Activity Relationship of Novel LSD1 Inhibitors Based on Pyrimidine-Thiourea Hybrids As Potent, Orally Active Antitumor Agents. | Ma LY, Zheng YC, Wang SQ, Wang B, Wang ZR, Pang LP, Zhang M, Wang JW, Ding L, Li J, Wang C, Hu B, Liu Y, Zhang XD, Wang JJ, Wang ZJ, Zhao W, Liu HM | J Med Chem |
| First-in-human study of the toxicity, pharmacokinetics, and pharmacodynamics of CG200745, a pan-HDAC inhibitor, in patients with refractory solid malignancies. | Kim KP, Park SJ, Kim JE, Hong YS, Lee JL, Bae KS, Cha H, Kwon SK, Ro S, Cho J, Kim TW | Invest New Drugs |
| Histone hypoacetylation and increased histone deacetylases in peripheral blood mononuclear cells from patients with Graves' disease. | Yan N, Zhou JZ, Zhang JA, Cai T, Zhang W, Wang Y, Muhali FS, Guan L, Song RH | Mol Cell Endocrinol |
| Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis. | Zhuo X, Guo X, Zhang X, Jing G, Wang Y, Chen Q, Jiang Q, Liu J, Zhang C | J Cell Biol |
| Repeated vapor ethanol exposure induces transient histone modifications in the brain that are modified by genotype and brain region | Finegersh A, Ferguson C, Maxwell S, Mazariegos D, Farrell D, Homanics GE | Front Mol Neurosci |
| Global histone modifications in Fumonisin B1 exposure in rat kidney epithelial cells. | Sancak D, Ozden S | Toxicol In Vitro |
| Top-down analysis of low mass proteins in exosomes shed by murine myeloid-derived suppressor cells. | Geis-Asteggiante L, Dhabaria A, Edwards N, Ostrand-Rosenberg S, Fenselau C | Int J Mass Spectrom |
| High Glucose Increases the Expression of Inflammatory Cytokine Genes in Macrophages Through H3K9 Methyltransferase Mechanism. | Li MF, Zhang R, Li TT, Chen MY, Li LX, Lu JX, Jia WP | J Interferon Cytokine Res |
| Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer. | Zhang L, Deng L, Chen F, Yao Y, Wu B, Wei L, Mo Q, Song Y | Oncotarget |
| Elevated expression of histone demethylase PHF8 associates with adverse prognosis in patients of laryngeal and hypopharyngeal squamous cell carcinoma. | Zhu G, Liu L, She L, Tan H, Wei M, Chen C, Su Z, Huang D, Tian Y, Qiu Y, Liu Y, Zhang X | Epigenomics |
| Top2a identifies and provides epigenetic rationale for novel combination therapeutic strategies for aggressive prostate cancer. | Kirk JS, Schaarschuch K, Dalimov Z, Lasorsa E, Ku S, Ramakrishnan S, Hu Q, Azabdaftari G, Wang J, Pili R, Ellis L | Oncotarget |
| Endometriosis is characterized by a distinct pattern of histone 3 and histone 4 lysine modifications. | Monteiro JB, Col??n-D??az M, Garc??a M, Gutierrez S, Col??n M, Seto E, Laboy J, Flores I | Reprod Sci |
| ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via ?±-ketoglutarate. | Keenan MM, Liu B, Tang X, Wu J, Cyr D, Stevens RD, Ilkayeva O, Huang Z, Tollini LA, Murphy SK, Lucas J, Muoio DM, Kim SY, Chi JT | PLoS Genet |
| Histone Methylation in Nickel-Smelting Industrial Workers. | Ma L, Bai Y, Pu H, Gou F, Dai M, Wang H, He J, Zheng T, Cheng N | PLoS One |
| Increased Acetylation of Histone H4 at Lysine 12 (H4K12) in Monocytes of Transgenic Alzheimer's Mice and in Human Patients. | Plagg B, Ehrlich D, Kniewallner KM, Marksteiner J, Humpel C | Curr Alzheimer Res |
| Cadmium induced apoptosis in mouse primary hepatocytes: the role of oxidative stress-mediated ERK pathway activation and the involvement of histone H3 phosphorylation | Wang J, Minglu Hao, Chunguang Liua, Rutao Liu | RSC Advances |
| Quadriceps muscle weakness and atrophy are associated with a differential epigenetic profile in advanced COPD. | Puig-Vilanova E, Mart??nez-Llorens J, Ausin P, Roca J, Gea J, Barreiro E | Clin Sci (Lond) |
| Novel Tranylcypromine/Hydroxylcinnamic Acid Hybrids as Lysine-Specific Demethylase 1 Inhibitors with Potent Antitumor Activity. | Han Y, Wu C, Lv H, Liu N, Deng H | Chem Pharm Bull (Tokyo) |
| Inhibition of Histone Deacetylases Enhances the Osteogenic Differentiation of Human Periodontal Ligament Cells | Huynh, N, Everts, V, Prasit Pavasant DDS.,PhD., Ruchanee Salingcarnboriboon Ampornaramveth DDS., PhD. | J Cell Biol |
| Epigenetic regulation of proliferation and invasion in hepatocellular carcinoma cells by CBP/p300 histone acetyltransferase activity. | Inagaki Y, Shiraki K, Sugimoto K, Yada T, Tameda M, Ogura S, Yamamoto N, Takei Y, Ito M | Int J Oncol |
| Apoptosis in human myelodysplastic syndrome CD34+ cells is modulated by the upregulation of TLRs and histone H4 acetylation via a ??-arrestin 1 dependent mechanism | Zeng Q, et al | Exp Cell Res |
| 3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1. | Wu F, Zhou C, Yao Y, Wei L, Feng Z, Deng L, Song Y | J Med Chem |
| Mono-2-ethylhexyl phthalate (MEHP) alters histiotrophic nutrition pathways and epigenetic processes in the developing conceptus. | Sant KE, Dolinoy DC, Jilek JL, Shay BJ, Harris C | J Nutr Biochem |
| Pharmacological priming of adipose-derived stem cells promotes myocardial repair. | Burchfield JS, Paul AL, Lanka V, Tan W, Kong Y, McCallister C, Rothermel BA, Schneider JW, Gillette TG, Hill JA | J Investig Med |
| Perinatal exposure to germinated brown rice and its gamma amino-butyric acid-rich extract prevents high fat diet-induced insulin resistance in first generation rat offspring. | Adamu HA, Imam MU, Ooi DJ, Esa NM, Rosli R, Ismail M | Food Nutr Res |
| EZH2 inhibition re-sensitizes multidrug resistant B-cell lymphomas to etoposide mediated apoptosis | Smonskey M, Lasorsa E, Rosario S, Kirk J, Hernandez-Ilizaliturri F, Ellis L | Oncoscience |
| Developmental lead exposure and lifespan alterations in epigenetic regulators and their correspondence to biomarkers of Alzheimer's disease | Eid A, Bihaqi S, Renehan W, Zawaia N | Alzheimer's and Dement |
| Effects of Wutou Decoction on DNA Methylation and Histone Modifications in Rats with Collagen-Induced Arthritis | Liu Y, Wen C, Chen Z, Wang Y, Huang Y, Hu Y, Tu S | Evid. Based Complement. Alternat. Med. |
| H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus. | Snigdha S, Prieto GA, Petrosyan A, Loertscher BM, Dieskau AP, Overman LE, Cotman CW | J Neurosci |
| Curcumin ameliorates nephrosclerosis via suppression of histone acetylation independent of hypertension | Muta K, Obata Y, Oka S, Abe S, Minami K, Katamura M, Endo D, Koji T, Nishino T | Nephrol Dial Transplant |
| Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2. | Shearstone JR, Golonzhka O, Chonkar A, Tamang D, van Duzer JH, Jones SS, Jarpe MB | PLoS One |
| Histone lysine-crotonylation in acute kidney injury. | Ruiz-Andres O, Sanchez-Ni?±o MD, Cannata-Ortiz P, Ruiz-Ortega M, Egido J, Ortiz A, Sanz AB | Dis Model Mech |
| Ozone therapy could attenuate tubulointerstitial injury in adenine-induced CKD rats by mediating Nrf2 and NF-??B | Gang Yu, Xiuheng Liu, Zhiyuan Chen, Hui Chen, Lei Wang, Zhishun Wang, Tao Qiu, Xiaodong Weng | IJBMS |
| Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus. | Li N, Subrahmanyan L, Smith E, Yu X, Zaidi S, Choi M, Mane S, Nelson-Williams C, Bahjati M, Kazemi M, Hashemi M, Fathzadeh M, Narayanan A, Tian L, Montazeri F, Mani M, Begleiter ML, Coon BG, Lynch HT, Olson EN, Zhao H, Ruland J, Lifton RP, Mani A | Am J Hum Genet |
| Emodin inhibits breast cancer growth by blocking the tumor-promoting feedforward loop between cancer cells and macrophages. | Iwanowycz S, Wang J, Hodge J, Wang Y, Yu F, Fan D | Mol Cancer Ther |
| An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. | Vinogradova M, Gehling VS, Gustafson A, Arora S, Tindell CA, Wilson C, Williamson KE, Guler GD, Gangurde P, Manieri W, Busby J, Flynn EM, Lan F, Kim HJ, Odate S, Cochran AG, Liu Y, Wongchenko M, Yang Y, Cheung TK, Maile TM, Lau T, Costa M, Hegde GV, Jackson E, Pitti R, Arnott D, Bailey C, Bellon S, Cummings RT, Albrecht BK, Harmang | Nat Chem Biol |
| 1,2,3-Triazole-Dithiocarbamate Hybrids, a Group of Novel Cell Active SIRT1 Inhibitors. | Zheng YC, Wang LZ, Zhao LJ, Zhao LJ, Zhan QN, Ma JL, Zhang B, Wang MM, Wang ZR, Li JF, Liu Y, Chen ZS, Shen DD, Liu XQ, Ren M, Lv WL, Zhao W, Duan YC, Liu HM | Cell Physiol Biochem |
| Quiescence Loosens Epigenetic Constraints in Bovine Somatic Cells and Improves Their Reprogramming into Totipotency. | Kallingappa PK, Turner PM, Eichenlaub MP, Green AL, Oback FC, Chibnall AM, Wells DN, Oback B | Biol Reprod |
| Frontline Science: ATF3 is responsible for the inhibition of TNF-?± release and the impaired migration of acute ethanol-exposed monocytes and macrophages. | Hu C, Meng X, Huang C, Shen C, Li J | J Leukoc Biol |
| Dynamic Variation of Histone H3 Trimethyl Lys4 (H3K4me3) and Heterochromatin Protein 1 (HP1) with Employment Length in Nickel Smelting Workers. | Zhao Y, Cheng N, Dai M, Pu H, Zheng T, Li H, He J, Bai Y | Biomarkers |
| Characteristics and expression patterns of histone-modifying enzyme systems in the migratory locust. | Guo S, Jiang F, Yang P, Liu Q, Wang X, Kang L | Insect Biochem Mol Biol |
| Lack of global epigenetic methylation defects in CBS deficient mice. | Lee HO, Wang L, Kuo YM, Gupta S, Slifker MJ, Li YS, Andrews AJ, Kruger WD | J Inherit Metab Dis |
| Tip60 HAT Action Mediates Environmental Enrichment Induced Cognitive Restoration. | Xu S, Panikker P, Iqbal S, Elefant F | PLoS One |
| Abnormal histone acetylation of CD8+ T cells in patients with severe aplastic anemia. | Qi W, Yan L, Liu C, Fu R, Wang H, Shao Z | Int J Hematol |
| Histone deacetylase inhibition is cytotoxic to oligodendrocyte precursor cells in vitro and in vivo. | Dincman TA, Beare JE, Ohri SS, Gallo V, Hetman M, Whittemore SR | Int J Dev Neurosci |
| miR-15b facilitates the progression of colorectal cancer via targeting ??-catenin and Axin2 | Xiong Guo, Yang Zhang, Jian Li, Mingmei Liao | IJCEP |
| Dietary Flavones as Dual Inhibitors of DNA Methyltransferases and Histone Methyltransferases. | Kanwal R, Datt M, Liu X, Gupta S | PLoS One |
| CD47 is a Potential Target for the Treatment of Laryngeal Squamous Cell Carcinoma. | Yang C, Gao S, Zhang H, Xu L, Liu J, Wang M, Zhang S | Cell Physiol Biochem |
| Mutations in Histone Acetylase Modifier BRPF1 Cause an Autosomal-Dominant Form of Intellectual Disability with Associated Ptosis | Francesca Mattioli, Elise Schaefer, Alex Magee, Paul Mark, Grazia M. Mancini, Klaus Dieterich, Gretchen Von Allmen et al. | AJHG |
| Development of Improved HDAC6 Inhibitors as Pharmacological Therapy for Axonal Charcot-Marie-Tooth Disease. | Benoy V, Vanden Berghe P, Jarpe M, Van Damme P, Robberecht W, Van Den Bosch L | Neurotherapeutics |
| Selective Inhibitors of Histone Deacetylases 1 and 2 Synergize with Azacitidine in Acute Myeloid Leukemia. | Min C, Moore N, Shearstone JR, Quayle SN, Huang P, van Duzer JH, Jarpe MB, Jones SS, Yang M | PLoS One |
| Phosphorylated Histone 3 at Serine 10 Identifies Activated Spinal Neurons and Contributes to the Development of Tissue Injury-Associated Pain. | Torres-P??rez JV, S??ntha P, Varga A, Szucs P, Sousa-Valente J, Gaal B, Sivad?? M, Andreou AP, Beattie S, Nagy B, Matesz K, C Arthur JS, Jancs?? G, Nagy I | Sci Rep |
| Histone H4 expression is cooperatively maintained by IKK?? and Akt1 which attenuates cisplatin-induced apoptosis through the DNA-PK/RIP1/IAPs signaling cascade. | Wang R, Zheng X, Zhang L, Zhou B, Hu H, Li Z, Zhang L, Lin Y, Wang X | Sci Rep |
| Involvement of histone methylation in macrophage apoptosis and unstable plaque formation in methionine-induced hyperhomocysteinemic ApoE<sup>-/-</sup> mice. | Cong G, Yan R, Huang H, Wang K, Yan N, Jin P, Zhang N, Hou J, Chen D, Jia S | Life Sci |
| In utero exposure to germinated brown rice and its oryzanol-rich extract attenuated high fat diet-induced insulin resistance in F1 generation of rats. | Adamu HA, Imam MU, Ooi DJ, Esa NM, Rosli R, Ismail M | BMC Complement Altern Med |
| Dose- and time- effect responses of DNA methylation and histone H3K9 acetylation changes induced by traffic-related air pollution. | Ding R, Jin Y, Liu X, Ye H, Zhu Z, Zhang Y, Wang T, Xu Y | Sci Rep |
| Alkylresorcinols activate SIRT1 and delay ageing in Drosophila melanogaster. | Kayashima Y, Katayanagi Y, Tanaka K, Fukutomi R, Hiramoto S, Imai S | Sci Rep |
| Citrullination/Methylation Crosstalk on Histone H3 Regulates ER-Target Gene Transcription. | Clancy KW, Russell AM, Subramanian V, Nguyen H, Qian Y, Campbell RM, Thompson PR | ACS Chem Biol |
| Loss of TET1 facilitates DLD1 colon cancer cell migration via H3K27me3-mediated down-regulation of E-cadherin. | Zhou Z, Zhang HS, Liu Y, Zhang ZG, Du GY, Li H, Yu XY, Huang YH | J Cell Physiol |
| Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in the MAM model for schizophrenia. | Gulchina Y, Xu SJ, Snyder MA, Elefant F, Gao WJ | J Neurochem |
| Response gene to complement-32 mediates TGF-??-induced epithelial-mesenchymal transition via Erk-/p38-MAPK signaling pathways in human pancreatic cancer cell line BxPC-3 | Liang Zhu, Ying Ding, Qiu Zhao | IJCEP |
| MicroRNA??‘320 regulates autophagy in retinoblastoma by targeting hypoxia inducible factor??‘1?± | Yong Liang, Xi Chen, Zhu Liang | Experimental and Theraputic Medicine |
| BEBT-908: A novel potent PI3K/HDAC inhibitor against diffuse large B-cell lymphoma. | Li J, Qian C, Zhou Q, Li J, Li K, Yi P | Biochem Biophys Res Commun |
| Oncometabolite d-2-hydroxyglutarate impairs ?±-ketoglutarate dehydrogenase and contractile function in rodent heart. | Karlstaedt A, Zhang X, Vitrac H, Harmancey R, Vasquez H, Wang JH, Goodell MA, Taegtmeyer H | Proc Natl Acad Sci U S A |
| Hepatic Lipid Accumulation and Nrf2 Expression following Perinatal and Peripubertal Exposure to Bisphenol A in a Mouse Model of Nonalcoholic Liver Disease | Shimpi P, More V, Paranjpe M, Donepudi A, Goodrich J, Dolinoy D, Beverly Rubin B, Slitt A. | Environmental Health Perspective |
| KDM4B-mediated reduction of H3K9me3 and H3K36me3 levels improves somatic cell reprogramming into pluripotency. | Wei J, Antony J, Meng F, MacLean P, Rhind R, Laible G, Oback B | Sci Rep |
| Chemoproteomics Reveals Chemical Diversity and Dynamics of 4-Oxo-2-nonenal Modifications in Cells. | Sun R, Fu L, Liu KK, Tian CP, Yang Y, Tallman KA, Porter NA, Liebler DC, Yang J | Mol Cell Proteomics |
| Systematic and quantitative assessment of hydrogen peroxide reactivity with cysteines across human proteomes. | Fu L, Liu KK, Sun MA, Tian CP, Sun R, Morales Betanzos C, Tallman KA, Porter NA, Yang Y, Guo DJ, Liebler DC, Yang J | Mol Cell Proteomics |
| Chronic exercise training activates histone turnover in mouse skeletal muscle fibers. | Ohsawa I, Kawano F | FASEB J |
| Novel detection of post-translational modifications in human monocyte-derived dendritic cells after chronic alcohol exposure: Role of inflammation regulator H4K12ac. | Parira T, Figueroa G, Laverde A, Casteleiro G, Gomez Hernandez ME, Fernandez-Lima F, Agudelo M | Sci Rep |
| The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat. | Long D, Wu H, Tsang AW, Poole LB, Yoza BK, Wang X, Vachharajani V, Furdui CM, McCall CE | Sci Rep |
| Sirt1 regulates apoptosis and extracellular matrix degradation in resveratrol??‘treated osteoarthritis chondrocytes via the Wnt/????‘catenin signaling pathways | Liu, S., Yang, H., Hu, B., Zhang, M. | Experimental and Therapeutic Medicine |
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| Human osteogenic differentiation in Space: proteomic and epigenetic clues to better understand osteoporosis. | Gambacurta A, Merlini G, Ruggiero C, Diedenhofen G, Battista N, Bari M, Balsamo M, Piccirillo S, Valentini G, Mascetti G, Maccarrone M | Sci Rep |
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| Epigenetic regulations in alternative telomere lengthening: Understanding the mechanistic insight in arsenic-induced skin cancer patients. | Bhattacharjee P, Das A, Giri AK, Bhattacharjee P | Sci Total Environ |
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| Histone H3K9 methylation is involved in? temporomandibular joint osteoarthritis. | Ukita M, Matsushita K, Tamura M, Yamaguchi T | Int J Mol Med |
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| Targeting the Histone Methyltransferase Disruptor of Telomeric Silencing 1-Like Restricts Avian Leukosis Virus Subgroup J Replication by Restoring the Innate Immune Response in Chicken Macrophages. | Chen S, Wang D, Liu Y, Zhao R, Wu T, Hu X, Pan Z, Cui H | Front Microbiol |
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| Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract. | Maddala R, Gao J, Mathias RT, Lewis TR, Arshavsky VY, Levine A, Backer JM, Bresnick AR, Rao PV | Sci Rep |
| Rice and Arabidopsis homologs of yeast CHROMOSOME TRANSMISSION FIDELITY PROTEIN 4 commonly interact with Polycomb complexes but exert divergent regulatory functions | Zhang P, et. al. | The Plant Cell |
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| Metformin Reduces Histone H3K4me3 at the Promoter Regions of Positive Cell Cycle Regulatory Genes in Lung Cancer Cells. | Kim D, Kim Y, Lee BB, Cho EY, Han J, Shim YM, Kim DH | Cancers (Basel) |
| Stimulation of the Serotonin Receptor 7 Restores Brain Histone H3 Acetylation and MeCP2 Corepressor Protein Levels in a Female Mouse Model of Rett Syndrome. | Napoletani G, Vigli D, Cosentino L, Grieco M, Talamo MC, Lacivita E, Leopoldo M, Laviola G, Fuso A, d'Erme M, De Filippis B | J Neuropathol Exp Neurol |
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| Pharmacological targeting of TNS3 with histone deacetylase inhibitor as a therapeutic strategy in esophageal squamous cell carcinoma. | Shi Y, Xiang Z, Yang H, Khan S, Li R, Zhou S, Ullah S, Zhang J, Liu B | Aging (Albany NY) |
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| Allyl sulfide promotes osteoblast differentiation and bone density via reducing mitochondrial DNA release mediated Kdm6b/H3K27me3 epigenetic mechanism. | Behera J, Ison J, Rai H, Tyagi N | Biochem Biophys Res Commun |
| Exendin-4 may improve type 2 diabetes by modulating the epigenetic modifications of pancreatic histone H3 in STZ-induced diabetic C57BL/6? J mice. | Tu P, Huang B, Li M, Zhang Y, Bao S, Tu N, Yang Y, Lu J | J Physiol Biochem |
| Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice. | Kim SP, Srivatsan SN, Chavez M, Shirai CL, White BS, Ahmed T, Alberti MO, Shao J, Nunley R, White LS, Bednarski J, Pehrson JR, Walter MJ | Cell Rep |
| Corticosterone dynamically regulates retrotransposable element expression in the rat hippocampus and C6 cells | Bartlett, A. A., et. al. | Neurobiology of Stress |
| Prenatal and postnatal traffic pollution exposure, DNA methylation in Shank3 and MeCP2 promoter regions, H3K4me3 and H3K27me3 and sociability in rats' offspring. | Zhou Q, Tian Y, Xu C, Wang J, Jin Y | Clin Epigenetics |
| Lactate supports a metabolic-epigenetic link in macrophage polarization. | Noe JT, Rendon BE, Geller AE, Conroy LR, Morrissey SM, Young LEA, Bruntz RC, Kim EJ, Wise-Mitchell A, Barbosa de Souza Rizzo M, Relich ER, Baby BV, Johnson LA, Affronti HC, McMasters KM, Clem BF, Gentry MS, Yan J, Wellen KE, Sun RC, Mitchell RA | Sci Adv |
| Histone H3 lysine-trimethylation markers are decreased by recombinant methioninase and increased by methotrexate at concentrations which inhibit methionine-addicted osteosarcoma cell proliferation. | Aoki Y, Tome Y, Han Q, Yamamoto J, Hamada K, Masaki N, Bouvet M, Nishida K, Hoffman RM | Biochem Biophys Rep |
| Epigenetic Silencing of OR and TAS2R Genes Expression in Human Orbitofrontal Cortex At Early Stages of Sporadic Alzheimer???s Disease | Cunha Alves, V., Figueiro-Silva, J.,Ferrer, I., Carro, E. | Research Square |
| Inhibition of class I HDACs preserves hair follicle inductivity in postnatal dermal cells. | Park M, Jang S, Chung JH, Kwon O, Jo SJ | Sci Rep |
| The long noncoding RNA H19 regulates tumor plasticity in neuroendocrine prostate cancer. | Singh N, Ramnarine VR, Song JH, Pandey R, Padi SKR, Nouri M, Olive V, Kobelev M, Okumura K, McCarthy D, Hanna MM, Mukherjee P, Sun B, Lee BR, Parker JB, Chakravarti D, Warfel NA, Zhou M, Bearss JJ, Gibb EA, Alshalalfa M, Karnes RJ, Small EJ, Aggarwal R, Feng F, Wang Y, Buttyan R, Zoubeidi A, Rubin M, Gleave M, Slack FJ, Davicioni E | Nat Commun |
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| The histone demethylase PHF8 regulates TGF?? signaling and promotes melanoma metastasis. | Moubarak RS, de Pablos-Aragoneses A, Ortiz-Barahona V, Gong Y, Gowen M, Dolgalev I, Shadaloey SAA, Argibay D, Karz A, Von Itter R, Vega-S??enz de Miera EC, Sokolova E, Darvishian F, Tsirigos A, Osman I, Hernando E | Sci Adv |
| Genome-wide analyses of histone modifications and chromatin accessibility reveal the distinct genomic compartments in the Irish potato famine pathogen Phytophthora infestans | Chen, H. et. al. | bioRxiv |
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| Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor. | Zhang X, Lou HE, Gopalan V, Liu Z, Jafarah HM, Lei H, Jones P, Sayers CM, Yohe ME, Chittiboina P, Widemann BC, Thiele CJ, Kelly MC, Hannenhalli S, Shern JF | Cell Rep |
| Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor. | Zhang X, Lou HE, Gopalan V, Liu Z, Jafarah HM, Lei H, Jones P, Sayers CM, Yohe ME, Chittiboina P, Widemann BC, Thiele CJ, Kelly MC, Hannenhalli S, Shern JF | Cell Rep |
| Decreased expression of EZH2 in granulosa cells contributes to endometriosis-associated infertility by targeting IL-1R2. | Lin X, Tong X, Zhang Y, Gu W, Huang Q, Zhang Y, Zhuo F, Zhao F, Jin X, Li C, Huang D, Zhang S, Dai Y | Endocrinology |
| EZH2 inhibition re-sensitizes multidrug resistant B-cell lymphomas to etoposide mediated apoptosis. | Smonskey M, Lasorsa E, Rosario S, Kirk JS, Hernandez-Ilizaliturri FJ, Ellis L | Oncoscience |
| An enhanced network of energy metabolism, lysine acetylation and growth-promoting protein accumulation is associated with heterosis in elite hybrid rice. | Ma X, Jia Q, Li S, Chen Z, Ming X, Zhao Y, Zhou DX | Plant Commun |
| Sulforaphane Potentiates Gemcitabine-Mediated Anti-Cancer Effects against Intrahepatic Cholangiocarcinoma by Inhibiting HDAC Activity. | Tomooka F, Kaji K, Nishimura N, Kubo T, Iwai S, Shibamoto A, Suzuki J, Kitagawa K, Namisaki T, Akahane T, Mitoro A, Yoshiji H | Cells |
| CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth. | Yin S, Liu L, Ball LE, Wang Y, Bedford MT, Duncan SA, Wang H, Gan W | Cell Rep |
| Regulation of endothelial-to-mesenchymal transition by histone deacetylase 3 posttranslational modifications in neointimal hyperplasia. | Chen L, He J, Zhang Y, Li Y, Zhang T, Wang R, Bai L, Zhao S, Liu E, Wang W | Ann Transl Med |
| Maternal immune activation alters placental histone-3 lysine-9 tri-methylation, offspring sensorimotor processing, and hypothalamic transposable element expression in a sex-specific manner. | DeRosa H, Smith A, Geist L, Cheng A, Hunter RG, Kentner AC | Neurobiol Stress |
| KDM4B down-regulation facilitated breast cancer cell stemness via PHGDH upregulation in H3K36me3-dependent manner. | Wang XY, Li HM, Xia R, Li X, Zhang X, Jin TZ, Zhang HS | Mol Cell Biochem |
| Gain-of-function mutations in the catalytic domain of DOT1L promote lung cancer malignant phenotypes via the MAPK/ERK signaling pathway. | Zhang J, Yang T, Han M, Wang X, Yang W, Guo N, Ren Y, Cui W, Li S, Zhao Y, Zhai X, Jia L, Yang J, Wu C, Wang L | Sci Adv |
| Discovery of new tetrahydroisoquinolines as potent and selective LSD1 inhibitors for the treatment of MLL-rearranged leukemia. | Yang C, Fang Y, Hu Y, Tian T, Liao G | Eur J Med Chem |
| ACL and HAT1 form a nuclear module to acetylate histone H4K5 and promote cell proliferation. | Xu Q, Yue Y, Liu B, Chen Z, Ma X, Wang J, Zhao Y, Zhou DX | Nat Commun |
| KDM2A interacts with estrogen receptor ?± to promote bisphenol A and S-induced breast cancer cell proliferation by repressing TET2 expression. | Li Z, Ren Y, Li X, Wang W | Ecotoxicol Environ Saf |
| Sucrose-nonfermenting 1 kinase activates histone acetylase GCN5 to promote cellulase production in Trichoderma. | Li Z, Cai C, Huo X, Li X, Lin Z | Appl Microbiol Biotechnol |
| Down-regulated Smyd1 participated in the inhibition of myoblast differentiation induced by cigarette smoke extract. | Li F, Xu M, Miao J, Hu N, Wang Y, Wang L | Toxicol Lett |
| Elovanoids are neural resiliency epigenomic regulators targeting histone modifications, DNA methylation, tau phosphorylation, telomere integrity, senescence programming, and dendrite integrity. | Bazan N, Bhattacharjee S, Kala-Bhattacharjee S, Ledet A, Mukherjee P | Res Sq |
| Hyperhomocysteinemia lowers serum testosterone concentration via impairing testosterone production in Leydig cells. | Su Z, Liu Z, Lei W, Xia K, Xiao A, Hu Z, Zhou M, Zhu F, Tian J, Yang M, Wang D, Xiang AP, Nie J | Cell Biol Toxicol |
| Pharmacological inhibition of histone deacetylases ameliorates cognitive impairment after intracerebral hemorrhage with epigenetic alteration in the hippocampus. | Okamura M, Inoue T, Takamatsu Y, Maejima H | J Stroke Cerebrovasc Dis |
| Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes. | Padalino G, Celatka CA, Rienhoff HY Jr, Kalin JH, Cole PA, Lassalle D, Forde-Thomas J, Chalmers IW, Brancale A, Grunau C, Hoffmann KF | Wellcome Open Res |
| Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer. | Sharma S, Chung CY, Uryu S, Petrovic J, Cao J, Rickard A, Nady N, Greasley S, Johnson E, Brodsky O, Khan S, Wang H, Wang Z, Zhang Y, Tsaparikos K, Chen L, Mazurek A, Lapek J, Kung PP, Sutton S, Richardson PF, Greenwald EC, Yamazaki S, Jones R, Maegley KA, Bingham P, Lam H, Stupple AE, Kamal A, Chueh A, Cuzzupe A, Morrow BJ, Ren B, | Cell Chem Biol |
| Unravelling blood-based epigenetic mechanisms: the impact of hsa-miR-146a and histone H3 acetylation in lead-induced inflammation among occupational workers. | Kiran GS, Kumar PK, Mitra P, Kumar K, Goyal T, Sharma S, Rana S, Sharma P | Int Arch Occup Environ Health |
| A DNA adenine demethylase impairs PRC2-mediated repression of genes marked by a specific chromatin signature. | Jia Q, Zhang X, Liu Q, Li J, Wang W, Ma X, Zhu B, Li S, Gong S, Tian J, Yuan M, Zhao Y, Zhou DX | Genome Biol |
| In Vivo Identification of H3K9me2/H3K79me3 as an Epigenetic Barrier to Carcinogenesis. | Piro MC, Gasperi V, De Stefano A, Anemona L, Cenciarelli CR, Montanaro M, Mauriello A, Catani MV, Terrinoni A, Gambacurta A | Int J Mol Sci |
| Reducing branched-chain amino acids improves cardiac stress response in mice by decreasing histone H3K23 propionylation. | Yang Z, He M, Austin J, Sayed D, Abdellatif M | J Clin Invest |
| TGF??1-RCN3-TGFBR1 loop facilitates pulmonary fibrosis by orchestrating fibroblast activation. | Wu M, Wang Z, Shi X, Zan D, Chen H, Yang S, Ding F, Yang L, Tan P, Ma RZ, Wang J, Ma L, Ma Y, Jin J | Respir Res |
| Epigenetic histone modification by butyrate downregulates KIT and attenuates mast cell function. | Gudneppanavar R, Sabu Kattuman EE, Teegala LR, Southard E, Tummala R, Joe B, Thodeti CK, Paruchuri S | J Cell Mol Med |
| Acetyl-methyllysine marks chromatin at active transcription start sites. | Lu-Culligan WJ, Connor LJ, Xie Y, Ekundayo BE, Rose BT, Machyna M, Pintado-Urbanc AP, Zimmer JT, Vock IW, Bhanu NV, King MC, Garcia BA, Bleichert F, Simon MD | Nature |
| Silver Nanoparticles Induced Changes in DNA Methylation and Histone H3 Methylation in a Mouse Model of Breast Cancer. | Brz??ska K, Sochanowicz B, Szczygie?? M, Drza?? A, ??niegocka M, Michalczyk-Wetula D, Elas M, Kapka-Skrzypczak L, Kruszewski M | Materials (Basel) |
| BML-281 promotes neuronal differentiation by modulating Wnt/Ca(2+) and Wnt/PCP signaling pathway. | Choi J, Gang S, Ramalingam M, Hwang J, Jeong H, Yoo J, Cho HH, Kim BC, Jang G, Jeong HS, Jang S | Mol Cell Biochem |
| SCD1-related epigenetic modifications affect hormone-sensitive lipase (Lipe) gene expression in cardiomyocytes. | Olichwier A, Sowka A, Balatskyi VV, Gan AM, Dziewulska A, Dobrzyn P | Biochim Biophys Acta Mol Cell Res |
| Acetyltransferases CBP/p300 control transcriptional switch of ??-catenin and Stat1 promoting osteoblast differentiation. | Zhang L, Zhu K, Xu J, Chen X, Sheng C, Zhang D, Yang Y, Sun L, Zhao H, Wang X, Tao B, Zhou L, Liu J | J Bone Miner Res |
| Photoaged Polystyrene Nanoplastics Result in Transgenerational Reproductive Toxicity Associated with the Methylation of Histone H3K4 and H3K9 in Caenorhabditis elegans. | Chen H, Gu Y, Jiang Y, Yu J, Chen C, Shi C, Li H | Environ Sci Technol |
| In Vivo Assessment of Hepatic and Kidney Toxicity Induced by Silicon Quantum Dots in Mice. | Cristian RE, Balta C, Herman H, Trica B, Sbarcea BG, Hermenean A, Dinischiotu A, Stan MS | Nanomaterials (Basel) |
| Vitamin B(12) is a limiting factor for induced cellular plasticity and tissue repair. | Kovatcheva M, Melendez E, Chondronasiou D, Pietrocola F, Bernad R, Caballe A, Junza A, Capellades J, Holgu??n-Horcajo A, Prats N, Durand S, Rovira M, Yanes O, Stephan-Otto Attolini C, Kroemer G, Serrano M | Nat Metab |
| Studies in CRISPR-generated Mediterranean G6PD variant rats reveal G6PD orchestrates genome-wide DNA methylation and gene expression in vascular wall. | Signoretti C, Gupte SA | bioRxiv |
| Impact of Electronic Cigarettes, Heated Tobacco Products and Conventional Cigarettes on the Generation of Oxidative Stress and Genetic and Epigenetic Lesions in Human Bronchial Epithelial BEAS-2B Cells. | Zarcone G, Lenski M, Martinez T, Talahari S, Simonin O, Gar?§on G, Allorge D, Nesslany F, Lo-Guidice JM, Platel A, Anth??rieu S | Toxics |
| The SMYD3-dependent H3K4me3 status of IGF2 intensifies local Th2 differentiation in CRSwNP via positive feedback. | Yu L, Wei Y, Lu T, Li Z, Lai S, Yan Y, Chen C, Wen W | Cell Commun Signal |
| The H2Bub1-deposition complex is required for human and mouse cardiogenesis. | Barish S, Berg K, Drozd J, Berglund-Brown I, Khizir L, Wasson LK, Seidman CE, Seidman JG, Chen S, Brueckner M | Development |
| Smyd1: Implications for novel approaches in rhabdomyosarcoma therapy. | Berkholz J, Schmitt A, Fragasso A, Schmid AC, Munz B | Exp Cell Res |
| Asymmetric and symmetric protein arginine methylation in methionine-addicted human cancer cells. | Holtz AG, Lowe TL, Aoki Y, Kubota Y, Hoffman RM, Clarke SG | PLoS One |
| Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells. | Cheng Z, Huang H, Li M, Chen Y | iScience |
| Histone H3 Acetylation Is Involved in Retinoid Acid-Induced Neural Differentiation through Increasing Mitochondrial Function. | Zhang Y, Wang X, Mu Q, Hou X, Yu W, Guo J | Biomedicines |
| The Effects of Larval Cryopreservation on the Epigenetics of the Pacific Oyster Crassostrea gigas. | Liu Y, Bao L, Catalano SR, Zhu X, Li X | Int J Mol Sci |
| Goji Berry Juice Prevents Tumor Necrosis Factor Alpha-Induced Xerostomia in Human Salivary Gland Cells. | Takakura M, Mizutani A, Kudo M, Ishikawa A, Okamoto T, Fu TX, Kurimoto SI, Koike Y, Mishima K, Tanaka J, Inoue T, Kawazoe K | Biol Pharm Bull |
| Disruption of H3K36 methylation provokes cellular plasticity to drive aberrant glandular formation and squamous carcinogenesis. | Ko EK, Anderson A, D'souza C, Zou J, Huang S, Cho S, Alawi F, Prouty S, Lee V, Yoon S, Krick K, Horiuchi Y, Ge K, Seykora JT, Capell BC | Dev Cell |
| Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice. | Li H, Kawatake-Kuno A, Inaba H, Miyake Y, Itoh Y, Ueki T, Oishi N, Murai T, Suzuki T, Uchida S | Neuron |
| Pharmacokinetics, pharmacodynamics and safety of oral formulation (CG-750) of ivaltinostat, a histone deacetylase inhibitor, compared to IV formulation (CG-745). | Kim B, Huh KY, Yu KS, Lee S | Br J Clin Pharmacol |
| Chromatin attachment to the nuclear matrix represses hypocotyl elongation in Arabidopsis thaliana. | Xu L, Zheng S, Witzel K, Van De Slijke E, Baekelandt A, Mylle E, Van Damme D, Cheng J, De Jaeger G, Inz?? D, Jiang H | Nat Commun |
| KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma. | Kim YY, Gryder BE, Sinniah R, Peach ML, Shern JF, Abdelmaksoud A, Pomella S, Woldemichael GM, Stanton BZ, Milewski D, Barchi JJ Jr, Schneekloth JS Jr, Chari R, Kowalczyk JT, Shenoy SR, Evans JR, Song YK, Wang C, Wen X, Chou HC, Gangalapudi V, Esposito D, Jones J, Procter L, O'Neill M, Jenkins LM, Tarasova NI, Wei JS, McMahon JB, O' | Nat Commun |
| Circulating tumor cell clustering modulates RNA splicing and polyadenylation to facilitate metastasis. | Wu Q, Gu Z, Shang B, Wan D, Zhang Q, Zhang X, Xie P, Cheng S, Zhang W, Zhang K | Cancer Lett |
| Loss of Ezh2 in the medial ganglionic eminence alters interneuron fate, cell morphology and gene expression profiles. | Rhodes CT, Asokumar D, Sohn M, Naskar S, Elisha L, Stevenson P, Lee DR, Zhang Y, Rocha PP, Dale RK, Lee S, Petros TJ | Front Cell Neurosci |
| Epigenetic modification of histone acetylation in the sensorimotor cortex after intracerebral hemorrhage. | Nishio T, Inoue T, Takamatsu Y, Mishima T, Takamura H, Soma K, Kondo Y, Okamura M, Ikegami R, Maejima H | Biomed Res |
| Histone deficiency and hypoacetylation in the aging retinal pigment epithelium. | Dubey SK, Dubey R, Prajapati SC, Jung K, Mohan K, Liu X, Roney J, Tian W, Abney J, Giarmarco MM, Hernandez AG, Liu J, Kleinman ME | Aging Cell |
| Screening H3 Histone Acetylation in a Wild Bird, the House Sparrow (Passer Domesticus). | Ray D, Sheldon EL, Zimmer C, Martin LB, Schrey AW | Integr Org Biol |
| Histone lactylation in macrophages is predictive for gene expression changes during ischemia induced-muscle regeneration. | Desgeorges T, Galle E, Zhang J, von Meyenn F, De Bock K | Mol Metab |
| Transcriptional Expression of Histone Acetyltransferases and Deacetylases During the Recovery of Acute Exercise in Mouse Hippocampus. | Qian P, Wang S, Zhang T, Wu J | J Mol Neurosci |
| PARP1 Inhibition Halts EBV+ Lymphoma Progression by Disrupting the EBNA2/MYC Axis. | Napoletani G, Soldan SS, Kannan T, Preston-Alp S, Vogel P, Maestri D, Caruso LB, Kossenkov A, Sobotka A, Lieberman PM, Tempera I | bioRxiv |
| AtHD2D is involved in regulating lateral root development and participates in abiotic stress response in Arabidopsis. | Chu Y, Duan R, Song H, Zhang W, Zhou Y, Ma Y, Yin X, Tian L, Ausin I, Han Z | J Plant Physiol |
| Histone H3K27 Demethylase SlJMJ3 Modulates Fruit Ripening in Tomato. | Li Z, Zeng J, Zhou Y, Ding X, Jiang G, Wu K, Jiang Y, Duan X | Plant Physiol |
| Lactylome analyses suggest systematic lysine-lactylated substrates in oral squamous cell carcinoma under normoxia and hypoxia. | Song F, Hou C, Huang Y, Liang J, Cai H, Tian G, Jiang Y, Wang Z, Hou J | Cell Signal |
| Mitochondrial Spare Respiratory Capacity Is Negatively Correlated with Nuclear Reprogramming Efficiency. | Zhou Y, Al-Saaidi RA, Fernandez-Guerra P, Freude KK, Olsen RK, Jensen UB, Gregersen N, Hyttel P, Bolund L, Aagaard L, Bross P, Luo Y | Stem Cells Dev |
| ??-Hexachlorocyclohexane triggers neuroinflammatory activity, epigenetic histone post-translational modifications and cognitive dysfunction. | Grieco M, Giorgi A, Giacovazzo G, Maggiore A, Ficch?? S, d'Erme M, Mosca L, Mignogna G, Maras B, Coccurello R | Ecotoxicol Environ Saf |
| Thyroid Hormone-mediated Histone Modification Protects Cortical Neurons From the Toxic Effects of Hypoxic Injury. | Abe K, Li J, Liu YY, Brent GA | J Endocr Soc |
| Activation of AMPK inhibits cervical cancer growth by hyperacetylation of H3K9 through PCAF. | Pan B, Liu C, Su J, Xia C | Cell Commun Signal |
| Lysine acetyltransferase 14 mediates TGF-??-induced fibrosis in ovarian endometrioma via co-operation with serum response factor. | Gong Y, Liu M, Zhang Q, Li J, Cai H, Ran J, Ma L, Ma Y, Quan S | J Transl Med |
| H3K18 lactylation accelerates liver fibrosis progression through facilitating SOX9 transcription. | Wu S, Li J, Zhan Y | Exp Cell Res |
| KCNK1 promotes proliferation and metastasis of breast cancer cells by activating lactate dehydrogenase A (LDHA) and up-regulating H3K18 lactylation. | Hou X, Ouyang J, Tang L, Wu P, Deng X, Yan Q, Shi L, Fan S, Fan C, Guo C, Liao Q, Li Y, Xiong W, Li G, Zeng Z, Wang F | PLoS Biol |
| Loss of Kmt2c or Kmt2d drives brain metastasis via KDM6A-dependent upregulation of MMP3. | Seehawer M, Li Z, Nishida J, Foidart P, Reiter AH, Rojas-Jimenez E, Goyette MA, Yan P, Raval S, Munoz Gomez M, Cejas P, Long HW, Papanastasiou M, Polyak K | Nat Cell Biol |
| Involvement of dysregulated hippocampal histone H3K9 methylation at the promoter of the BDNF gene in impaired memory extinction. | Oga K, Fuchikami M, Kobayashi H, Miyagi T, Fujita S, Fujita S, Okada S, Morinobu S | Psychopharmacology (Berl) |
| P7C3 ameliorates barium chloride-induced skeletal muscle injury activating transcriptomic and epigenetic modulation of myogenic regulatory factors. | Kim JW, Manickam R, Sinha P, Xuan W, Huang J, Awad K, Brotto M, Tipparaju SM | J Cell Physiol |
| Transgenerational reproductive toxicity induced by carboxyl and amino charged microplastics at environmental concentrations in Caenorhabditis elegans: Involvement of histone methylation. | Chen H, Chen X, Gu Y, Jiang Y, Guo H, Chen J, Yu J, Wang C, Chen C, Li H | Sci Total Environ |
| Epigenome-wide impact of MAT2A sustains the androgen-indifferent state and confers synthetic vulnerability in ERG fusion-positive prostate cancer. | Cacciatore A, Shinde D, Musumeci C, Sandrini G, Guarrera L, Albino D, Civenni G, Storelli E, Mosole S, Federici E, Fusina A, Iozzo M, Rinaldi A, Pecoraro M, Geiger R, Bolis M, Catapano CV, Carbone GM | Nat Commun |
| Epigenetic mechanisms differentially regulate blood pressure and renal dysfunction in male and female Npr1 haplotype mice. | Kumar P, Neelamegam K, Ramasamy C, Samivel R, Xia H, Kapusta DR, Pandey KN | FASEB J |
| Influenza Vaccination Mediates SARS-CoV-2 Spike Protein Peptide-Induced Inflammatory Response via Modification of Histone Acetylation. | Zuo Z, Mu Y, Qi F, Zhang H, Li Z, Zhou T, Guo W, Guo K, Hu X, Yao Z | Vaccines (Basel) |
| PHF6 cooperates with SWI/SNF complexes to facilitate transcriptional progression. | Mittal P, Myers JA, Carter RD, Radko-Juettner S, Malone HA, Rosikiewicz W, Robertson AN, Zhu Z, Narayanan IV, Hansen BS, Parrish M, Bhanu NV, Mobley RJ, Rehg JE, Xu B, Drosos Y, Pruett-Miller SM, Ljungman M, Garcia BA, Wu G, Partridge JF, Roberts CWM | Nat Commun |
| Connecting high-resolution 3D chromatin maps with cell division and cell differentiation at the root apical meristem. | Caballero L, Pasternak T, Riyazuddin R, P??rez-P??rez JM | Plant Cell Rep |
| Discovery of Novel Non-nucleoside DOT1L(R231Q) Inhibitors with Improved Pharmacokinetic Properties and Anti-lung Cancer Efficacy. | Tan Z, Guo N, Liu S, Li J, Chen Y, Cui J, Lei H, Jiang N, Wang L, Zhai X | J Med Chem |
| Age-related histone H3.3 accumulation associates with a repressive chromatin in mouse tibialis anterior muscle. | Masuzawa R, Rosa Flete HK, Shimizu J, Kawano F | J Physiol Sci |
| Discovery of first-in-class DOT1L inhibitors against the R231Q gain-of-function mutation in the catalytic domain with therapeutic potential of lung cancer. | Tan Z, Guo N, Cao Z, Liu S, Zhang J, Ma D, Zhang J, Lv W, Jiang N, Zang L, Wang L, Zhai X | Acta Pharm Sin B |
| Intergenerational epigenetic inheritance mediated by MYS-2/MOF in the pathogenesis of Alzheimer's disease. | Li Y, Bai H, Liu W, Zhou W, Gu H, Zhao P, Zhu M, Li Y, Yan X, Zhao N, Huang X | iScience |
| Transcriptome and acetylome profiling identify crucial steps of neuronal differentiation in Rubinstein-Taybi syndrome. | Van Gils J, Karkar S, Barre A, Ley-Ngardigal S, Nothof S, Claverol S, Tokarski C, Trani JP, Chevalier R, Broucqsault N, El Yazidi C, Lacombe D, Fergelot P, Magdinier F | Commun Biol |
| GLP-1R activation attenuates the progression of pulmonary fibrosis via disrupting NLRP3 inflammasome/PFKFB3-driven glycolysis interaction and histone lactylation. | Liu C, Zhang Q, Zhou H, Jin L, Liu C, Yang M, Zhao X, Ding W, Xie W, Kong H | J Transl Med |
| Identification of the Regulatory Elements and Protein Substrates of Lysine Acetoacetylation. | Fu Q, Nguyen T, Kumar B, Azadi P, Zheng YG | bioRxiv |
| Loss of SETD2 in wild-type VHL clear cell renal cell carcinoma sensitizes cells to STF-62247 and leads to DNA damage, cell cycle arrest, and cell death characteristic of pyroptosis. | Johnson M, Turcotte S | Mol Oncol |
| LRH-1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype. | Cobo-Vuilleumier N, Rodr??guez-Fernandez S, L??pez-Noriega L, Lorenzo PI, Franco JM, Lachaud CC, Vazquez EM, Legido RA, Dorronsoro A, L??pez-F??rnandez-Sobrino R, Fern??ndez-Santos B, Serrano CE, Salas-Lloret D, van Overbeek N, Ramos-Rodriguez M, Mateo-Rodr??guez C, Hidalgo L, Marin-Canas S, Nano R, Arroba AI, Caro AC, Vertegaal AC, Mont | Clin Transl Med |
| Kdm2a inhibition in skeletal muscle improves metabolic flexibility in obesity. | Wang Y, Xie H, Liu Q, Wang N, Luo X, Sun F, Zhu J, Dong R, Wang Y, Gao J, Gao Z, Huang T, Liu X, Yu Q, Wang T, Li Y, Song D, Liu S, Zhang S, Yin H, Kong W, Wang CY | Nat Metab |
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