Coagulation factor VIII participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
序列
该Recombinant Human Factor VIII Protein的序列请参考该产品的说明书
来源宿主
Chinese Hamster Ovarian Cells (CHO)
溶解建议
该Recombinant Human Factor VIII Protein的溶解建议请参考该产品的说明书
保存建议
该Recombinant Human Factor VIII Protein的保存建议请参考该产品的说明书
其他
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