Mitogen-activated protein kinase 1 (MAPK1) is also known as "extracellular signal-regulated kinase 2" (ERK2). Two similar (85% sequence identity) protein kinases were originally called ERK1 and ERK2. They were found during a search for protein kinases that are rapidly phosphorylated after activation of cell surface tyrosine kinasessuch as the epidermal growth factor receptor. Phosphorylation of ERKs leads to the activation of their kinase activity.
The molecular events linking cell surface receptors to activation of ERKs are complex. It was found that RasGTP-binding proteins are involved in the activation of ERKs. Another protein kinase, Raf-1, was shown to phosphorylate a "MAPK kinase", thus qualifying as a "MAPK kinase kinase". The MAPK kinase was named "MAPK/ERK kinase" (MEK). Receptor-linked tyrosine kinases, Ras, Raf, MEK and MAPK could be fitted into a signaling cascade linking an extracellular signal to MAPK activation.Transgenic gene knockoutmice lacking MAPK1 have major defects in early development. MAPK1 Human Recombinant is a non-glycosylated full length chain containing amino acids Met1-Ser360.
序列
该MAPK1 Protein的序列请参考该产品的说明书
来源宿主
E. Coli
溶解建议
该MAPK1 Protein的溶解建议请参考该产品的说明书
保存建议
该MAPK1 Protein的保存建议请参考该产品的说明书
其他
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