Mesenchymal epithelial transition factor (c-MET) is a proto-oncogenic receptor tyrosine kinase. The endogenous ligand for c-MET is HGF (hepatocyte growth factor), which is a disulfide-linked heterodimeric molecule produced predominantly by mesenchymal cells. In the adult, c-MET protein expression is limited to stem and progenitor cells and is required for wound healing and hepatocyte regeneration. In the embryo, c-MET receptors are expressed on cells of epithelial origin, which are vital for invasive growth and mediate epithelial-mesenchymal transition (EMT). Abnormal activation of the HGF/MET pathway leads to a variety of cancers. c-MET mutation is linked with a poor prognosis since it can trigger tumor growth, angiogenesis and metastasis. Product Description: Met Proto-Oncogene Human Recombinant produced in Insect cells amino acids 1039-1345.
序列
该MET Protein的序列请参考该产品的说明书
来源宿主
Insect cells.
溶解建议
该MET Protein的溶解建议请参考该产品的说明书
保存建议
该MET Protein的保存建议请参考该产品的说明书
其他
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