Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:1533935, PubMed:14532120, PubMed:23872679). Functions in general as heterodimer with IFNAR2 (By similarity). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:14532120). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (PubMed:23872679). Contributes to modulate the innate immune response to bacterial lipopolysaccharide (PubMed:23872679).
序列
该IFNAR1 Recombinant Protein的序列请参考该产品的说明书
来源宿主
E.coli
溶解建议
该IFNAR1 Recombinant Protein的溶解建议请参考该产品的说明书
保存建议
该IFNAR1 Recombinant Protein的保存建议请参考该产品的说明书
其他
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