Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
序列
该PPP1CB Recombinant Protein (Human)的序列请参考该产品的说明书
来源宿主
该PPP1CB Recombinant Protein (Human)的来源宿主请参考该产品的说明书
溶解建议
该PPP1CB Recombinant Protein (Human)的溶解建议请参考该产品的说明书
保存建议
该PPP1CB Recombinant Protein (Human)的保存建议请参考该产品的说明书
其他
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