Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.
序列
该MDC1 Recombinant Protein (Human)的序列请参考该产品的说明书
来源宿主
该MDC1 Recombinant Protein (Human)的来源宿主请参考该产品的说明书
溶解建议
该MDC1 Recombinant Protein (Human)的溶解建议请参考该产品的说明书
保存建议
该MDC1 Recombinant Protein (Human)的保存建议请参考该产品的说明书
其他
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